Mechanisms of Isolevuglandin-protein Adduct Formation in Inflammation and Hypertension

Publication date: Available online 29 September 2018Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Liang Xiao, David M. Patrick, Luul A. Aden, Annet KiraboAbstractInflammation has been implicated in the pathogenesis of hypertension and recent evidence suggests that isolevuglandin (IsoLG)-protein adducts play a role. Several hypertensive stimuli contribute to formation of IsoLG-protein adducts including excess dietary salt and catecholamines. The precise intracellular mechanisms by which these hypertensive stimuli lead to IsoLG-protein adduct formation are still not well understood; however, there is now evidence implicating NADPH-oxidase derived reactive oxygen species (ROS) in this process. ROS oxidize arachidonic acid leading to formation of IsoLGs, which non-covalently adduct to lysine residues and alter protein structure and function. Recent studies suggest that these altered proteins act as neo-antigens leading to an autoimmune state that results in hypertension. The goal of this mini-review is to highlight some of the hypertensive stimuli and the mechanisms contributing to IsoLG-protein adduct formation leading to inflammation and hypertension.

Source: Prostaglandins and Other Lipid Mediators - October 4, 2018 Category: Lipidology Source Type: research