Ubiquitination at the interface of tumor viruses and DNA damage responses

Publication date: October 2018Source: Current Opinion in Virology, Volume 32Author(s): Joseph M Dybas, Christin Herrmann, Matthew D WeitzmanViruses exploit cellular ubiquitination machinery to shape the host proteome and promote productive infection. Among the cellular processes influenced by viral manipulation of ubiquitination is the DNA damage response (DDR), a network of cellular signaling pathways that sense and respond to genomic damage. This host–pathogen interaction is particularly important during virus replication and transformation by DNA tumor viruses. Manipulating DDR pathways can promote virus replication but also impacts host genomic instability, potentially leading to cellular transformation and tumor formation. We review ways in which viruses are known to hijack the cellular ubiquitin system to reshape host DDR pathways.

Source: Current Opinion in Virology - October 4, 2018 Category: Virology Source Type: research