Neonatal HCMV-related polymicrogyria in seroimmune women: what is the optimal pregnancy management?

Congenital HCMV is the most common congenital infection in developed countries with vertical transmission occurring following both primary (32%) and non-primary (1.4%) maternal infection. [1]. In the latter, whether congenital infection is a consequence of maternal reactivation of the latent HCMV strain(s), or of maternal reinfection with a new strain, is an issue that remains undefined. However, recent studies have argued that maternal super-infection with a serologically distinct HCMV strain could play a significant role in congenital HCMV infection [2].

Source: Journal of Clinical Virology - October 3, 2018 Category: Virology Authors: Maurizio Zavattoni, Giuseppina Lombardi, Francesca Garofoli, Guido Scalia, Annalisa Rizzo, Micol Angelini, Antonella Sarasini, Milena Furione, Fausto Baldanti Source Type: research