Chapter Three - Molecular Modeling for Better Understanding of Cucumovirus Pathology

Publication date: 2018Source: Advances in Virus Research, Volume 102Author(s): Katalin Salánki, Ákos Gellért, Katalin Nemes, Zoltán Divéki, Ervin BalázsAbstractCucumber mosaic virus (CMV) is a small RNA virus capable of infecting a wide variety of plant species. The high economic losses due to the CMV infection made this virus a relevant subject of scientific studies, which were further facilitated by the small size of the viral genome. Hence, CMV also became a model organism to investigate the molecular mechanism of pathogenesis. All viral functions are dependent on intra- and intermolecular interactions between nucleic acids and proteins of the virus and the host. This review summarizes the recent data on molecular determinants of such interactions. A particular emphasis is given to the results obtained by utilizing molecular-based planning and modeling techniques.

Source: Advances in Virus Research - October 4, 2018 Category: Virology Source Type: research