Homologation of Ugi and Passerini reactions using ynamides

Publication date: Available online 20 September 2018Source: Drug Discovery Today: TechnologiesAuthor(s): Bo Huang, Sunliang CuiBeing important biological and pharmacological units, β-amino amides and β-acyloxy amides have a privileged position in both academia and industry. Developing a methods to prepare them has gained attention. Ynamides, which possess dual nucleophilic and electrophilic properties, are similar to isonitriles. In this review, usage of ynamides in the single reactant replacement approach of Ugi and Passerini reactions to develop two new multicomponent reactions to get various β-amino amides and β-acyloxy amides is reported.
Source: Drug Discovery Today: Technologies - Category: Drugs & Pharmacology Source Type: research