Mammographic breast density refines Tyrer-Cuzick estimates of breast cancer risk in high-risk women: findings from the placebo arm of the International Breast Cancer Intervention Study I

Conclusions:
In women at high risk of breast cancer, adjusting percent mammographic density for age and BMI provides additional predictive information to the TC risk score, which already incorporates BMI, age, family history and other classic breast cancer risk factors. Furthermore, simple selection criteria can be developed using mammographic density, age and BMI to identify women at increased risk in a clinical setting.Clinical trial registration numberhttp://www.controlled-trials.com/ISRCTN91879928 (Registered: 1 June 2006).

Source: Breast Cancer Research - October 8, 2014 Category: Cancer & Oncology Authors: Jane WarwickHanna BirkeJennifer StoneRuth WarrenElizabeth PinneyAdam BrentnallStephen DuffyAnthony HowellJack Cuzick Source Type: research