Quality of life across domains among individuals with treatment-resistant depression

Depression is a common, debilitating illness that often fails to respond to first- and second-line treatments. For example, about one-third of patients did not reach remission after multiple optimized pharmacologic trials during the STAR-D study (Rush et al., 2006). Recent estimates for treatment resistant depression (TRD), often defined by two or more treatment failures, indicate a 12-month prevalence rate of approximately 2% in the US (Nemeroff, 2007). Furthermore, long-term outcomes of TRD are typically very poor.

Source: Journal of Affective Disorders - September 19, 2018 Category: Neurology Authors: Heidemarie Lex, Yarden Ginsburg, Adam F. Sitzmann, Clara Grayhack, Daniel F. Maixner, Brian J. Mickey Tags: Research paper Source Type: research