Within-Host Evolution of Virus Variants during Chronic Infection with Novel GII.P26-GII.26 Norovirus
Noroviruses, a genus of Caliciviridae, are small non-enveloped viruses and a leading cause of acute gastroenteritis [1]. They are easily spread by the fecal-oral route, as viral particles are highly contagious and largely unaffected by cold and heat inactivation, or exposure to detergent-based cleaners [2]. Norovirus infections cause a rapidly self-limiting illness with vomiting and diarrhea. Mainly elderly, infant and immunocompromised patients tend to suffer from severe disease [3]. Especially in the immunocompromised, chronic norovirus infections occur, associated with persistent shedding of infectious norovirus in stool [4].
Source: Journal of Clinical Virology - Category: Virology Authors: Corinna Pietsch, Nora Ennuschat, Sabine H ärtel, Uwe G. Liebert Source Type: research