Runs of homozygosity and population history of three horse breeds with small population size

Long consecutive homozygous genotype segments, runs of homozygosity (ROH), are a result of parents transmitting identical haplotypes, which can be used to estimate autozygosity. Based on 612K single nucleotide polymorphisms (SNPs) we computed three ROH parameters (genome length covered by ROH SROH, number of ROH NROH, and autozygosity FROH) to investigate different scenarios in contemporary horse breeding: limited census (Bosnian Mountain Horse), conservation breeding (Posavje Horse), and selection within closed studbook (Haflinger).
Source: Journal of Equine Veterinary Science - Category: Veterinary Research Authors: Source Type: research