Sandhoff Disease Mouse

Also known as:Hexbtm1Rlp,Hexb KO mouseHexb KO mice develop motor defects beginning at about 3 months of age. The defects progressively worsen and homozygous mice die by 4.5 months of age. Mice display gangliosidosis; mice abnormally accumulate GM2 and GA2 ganglioside and serve as a model of Sandhoff disease. Learn more onPubMed.Mice can be obtained from Jackson Labs.
Source: NIDDK Research Resources - Category: Endocrinology Source Type: research