Floxed Ugcg Mouse

Also known as:Ugcgtm4Rlp, floxed glucosylceramide synthase mouse, floxedGlcT mouseUgcgtm4Rlp allele has  loxp sites in intron 6 and in the 3 ’ untranslated region.  Cre expression would be predicted to delete exons 6,7,8 and 9.  Cre recombinase expression in the nervous system under control of thenestin promoter causes a substantial reduction ofUgcg expression and of ganglioside content. The mice deficient inUgcg expression in the nervous system showa loss of Purkinje cells and abnormal neurologic behavior. Learn more onPubMed.Mice can be obtained from MMRRC.
Source: NIDDK Research Resources - Category: Endocrinology Source Type: research