Floxed Sptlc1 Mouse

Also known as:Sptlc1tm1.1RlpTheSptlc1tm1.1Rlp  allele  has loxp sites flanking exons 4 and 5.  When the Cre gene is expressed under the control of the Adipoq promotor, theSptlc1 expression and sphingolipid levels is reduced in adipocytes.  The mice are useful for producing the conditional disruption of theSptlc1, an essential subunit of serine palmitoyl transferase. Learn more onPubMed.Mice can be obtained from MMRRC.
Source: NIDDK Research Resources - Category: Endocrinology Source Type: research