Sgpp2 KO Mouse

Also known as:Sgpp2tm1Rlp, sphingosine-1-phosphate (S1P) phosphatase 2 KO mouseIntracellular metabolism of sphingosine-1-phosphate (S1P) is controlled, in part, by two homologous S1P phosphatases (SPPases), 1 and 2, which are encoded by theSgpp1 andSgpp2 genes, respectively. SPPase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway.Sgpp2 KO mice exhibit decreased adaptive pancreatic β-cell proliferation and β-cell endoplasmic reticulum stress, revealing the importance of the sphingolipid recycling pathway in β-cell physiology. Learn more onPubMed.Mice can be obtained by contacting the NIDDK Technology Advancement Office.
Source: NIDDK Research Resources - Category: Endocrinology Source Type: research