Global methylation patterns in Primary Plasma Cell Leukemia

Plasma cell leukemia (PCL) is a rare form of PC dyscrasia diagnosed by the presence of more than 20% of PCs in peripheral blood and/or an absolute PC count ≥ 2 × 109 /L [1–4]. It may occur de novo, as primary PCL (pPCL), or as secondary PCL (sPCL) from the leukemic transformation of relapsed/refractory multiple myeloma (MM) [1–4]. Main chromosomal aberrations observed in MM, with the exception of hyperdiploidy, are also identified in pPCL, a lbeit with peculiar frequencies [5–7]. Additionally, specific gene and miRNA expression profiles, and mutational patterns distinguish pPCL from MM [5,8–10].

Source: Leukemia Research - September 18, 2018 Category: Hematology Authors: Katia Todoerti, Giovanni Calice, Stefania Trino, Vittorio Simeon, Marta Lionetti, Martina Manzoni, Sonia Fabris, Marzia Barbieri, Alessandra Pompa, Luca Baldini, Valentina Bollati, Pietro Zoppoli, Antonino Neri, Pellegrino Musto Tags: Research paper Source Type: research