Does loss of hormonal receptors influence the pathophysiological characteristics of the HER-2 breast cancer phenotype?

ConclusionLoss of HR does not influence the biological features of HER-2 BC. This finding may indicate that some tumors will ‘biologically’ move from being HER-2-positive/HR-positive tumors to behaving more like HER-2-positive/HR-negative tumors even when ER are present on the cell surface. Further studies are needed to explore this hypothesis and to identify the subset of tumors that will benefit from endocrine therapy.
Source: Pathophysiology - Category: Pathology Source Type: research