Effect of matrix metalloproteinase 8 inhibitor and chlorhexidine on the cytotoxicity, oxidative stress and cytokine level of MDPC-23

The deterioration of resin –dentin bonds has become a focus of research in contemporary adhesive dentistry due to the proteolysis of collagen matrix of the hybrid layers [1]. Chlorhexidine (CHX), a nonspecific protease inhibitor of matrix metalloproteinase (MMP) and cysteine cathepsins, has been found to be beneficial to ma intaining the integrity of the hybrid layer and preventing the loss of bond strength with time [2,3]. However, emerging evidence suggests that CHX exhibits both cytotoxicity and genotoxicity to oral cells, which greatly restricts its application in adhesive dentistry [4–6].

Source: Dental Materials - September 17, 2018 Category: Materials Science Authors: Qianmin Ou, Lingping Tan, Xiaojun Huang, Qipei Luo, Yan Wang, Xuefeng Lin Source Type: research