TNF- α suppresses osteogenic differentiation of MSCs by accelerating P2Y2 receptor in estrogen-deficiency induced osteoporosis
Tumor Necrosis Factor- α (TNF-α)-inhibited osteogenic differentiation of mesenchymal stem cells (MSCs) contributes to impaired bone formation, which plays a central role in the pathogenesis of postmenopausal osteoporosis. However, the exact mechanisms of TNF-α-inhibited osteoblast differentiation have not been fully el ucidated. Multiple P2 purinoceptor subtypes are expressed in several species of osteoblasts and are confirmed to regulate bone metabolism. The purpose of this study is to investigate whether P2 purinoceptors are involved in TNF-α-inhibited osteoblast differentiation.
Source: Bone - Category: Orthopaedics Authors: Di Du, Zhibin Zhou, Lei Zhu, Xianteng Hu, Jiajia Lu, Changgui Shi, Fangjing Chen, Aimin Chen Tags: Full Length Article Source Type: research