Hepatitis a virus-induced severe hemolysis complicated by severe Glucose-6-Phosphate Dehydrogenase deficiency

Dhruva Sharma, Omender Singh, Deven Juneja, Amit Goel, Suneel Kumar Garg, Shashank ShekharIndian Journal of Critical Care Medicine 2018 22(9):670-673 Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an x-linked recessive genetic disorder with mutation in the G6PD gene. Defect in the enzyme G6PD causes red blood cells (RBCs) to breakdown prematurely causing hemolytic anemia. Hemolytic anemia is also a known hematological complication associated with viral hepatitis. In such patients, hemolysis may be more severe if there is any secondary injury to RBC in the form of membrane defect, oxidative stress, or enzyme deficiency like in G6PD deficiency. Here, we present a case of an adult, not previously diagnosed with G6PD deficiency, who presented with viral hepatitis, severe hemolysis, and multiorgan failure.
Source: Indian Journal of Critical Care Medicine - Category: Intensive Care Authors: Source Type: research