Response inhibition and fronto-striatal-thalamic circuit dysfunction in cocaine addiction

Cocaine addiction is a debilitating and relapsing disorder (McLellan et al., 2000; Yuferov et al., 2005). Previous work has suggested deficits in cognitive control as an etiological process of habitual drug use in cocaine addiction (Ersche et al., 2011; Garavan and Hester, 2007; Goldstein and Volkow, 2011). Cortical and subcortical dysfunction has been suggested in brain imaging studies of addictions to cocaine or other stimulants (Aron and Paulus, 2007; Goldstein and Volkow, 2011; Hanlon et al., 2009; Hanlon et al., 2011; Hester and Garavan, 2004; Kaufman et al., 2003; Moeller et al., 2005; Peters et al., 2016; Wesley et al., 2011; Zhang et al., 2018).

Source: Drug and Alcohol Dependence - September 16, 2018 Category: Addiction Authors: Wuyi Wang, Patrick D. Worhunsky, Sheng Zhang, Thang M. Le, Marc N. Potenza, Chiang-Shan R. Li Tags: Full length article Source Type: research