Ustekinumab for the treatment of psoriasis: an evidence update.

Ustekinumab for the treatment of psoriasis: an evidence update.
Semin Cutan Med Surg. 2018 Sep;37(3):143-147
Authors: Yiu ZZ, Warren RB
Abstract
Ustekinumab is an interleukin-12/23 inhibitor used for the treatment of moderate-to-severe psoriasis. Here, we review new evidence since ustekinumab was licensed for relative efficacy in comparison with other biologic therapies from head-to-head randomized controlled trials and network meta-analyses for the treatment of psoriasis. We also review observational data emerging from psoriasis registries reporting the effectiveness and safety of ustekinumab. Overall, new evidence suggests that ustekinumab has a favorable balance between efficacy/effectiveness, safety, and tolerability and should remain a first-line biologic therapy option for patients with severe psoriasis at present.
PMID: 30215630 [PubMed - in process]

Source: Seminars in Cutaneous Medicine and Surgery - September 16, 2018 Category: Dermatology Tags: Semin Cutan Med Surg Source Type: research