Mineralocorticoid receptor function and cognition in health and disease

Stress, such as early life adversity or traumatic life events, is a risk factor for many psychiatric disorders including major depressive disorder (MDD) (Otte et al., 2016), posttraumatic stress disorder (PTSD), or borderline personality disorder (BPD) (Wingenfeld and Wolf, 2015). All of these disorders are characterized by alterations in cognitive and emotional function and by dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis leading to altered secretion of the stress hormone cortisol (Wingenfeld and Wolf, 2015).
Source: Psychoneuroendocrinology - Category: Psychiatry Authors: Source Type: research