Circulating epinephrine is not required for chronic stress to enhance metastasis

Beta-adrenergic receptor ( βAR) signaling has been identified as a target to modulate cancer progression. Preclinical studies in many types of cancer found that βAR signaling drives cancer progression, and identified molecular and cellular mechanisms (Thaker et al., 2006, Nissen et al., 2018, Le et al., 2016, Kim-Fuchs et a l., 2014, Lamkin et al., 2012, Sloan et al., 2010, Kim et al., 2016). These studies discovered that βAR signaling in tumor cells drives tumor cell invasion by enhancing formation of invadopodia, resulting in increased metastasis in vivo (Chang et al., 2016, Pon et al., 2016, Kim et al., 2016, Creed et al., 2015).

Source: Psychoneuroendocrinology - September 15, 2018 Category: Psychiatry Authors: Adam K. Walker, Davide Martelli, Alexandra I. Ziegler, Gavin W. Lambert, Sarah E. Phillips, Stephen J. Hill, Robin M. McAllen, Erica K. Sloan Source Type: research