Comparative efficacy of antibiotics in treating experimental Clostridium septicum infection

Clostridium septicum is a Gram-positive, anaerobic spore-forming pathogen that produces fatal infections in both healthy humans and animals [1]. In humans, C. septicum causes gas gangrene in normal hosts following deep penetrating or crushing injuries after trauma. C. septicum is also recognized as the principal cause of ‘spontaneous’ or ‘atraumatic’ gas gangrene in patients suffering from gastrointestinal maladies, including adenocarcinoma of the colon [2]. Due to the clinical challenges posed by spontaneous C.
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Source Type: research