Prothrombotic response to norepinephrine infusion, mimicking norepinephrine stress-reactivity effects, is partly mediated by α-adrenergic mechanisms

Between 10% and 50% of patients with an acute coronary syndrome (ACS) report an emotional trigger like mental stress or intense feelings within 2  h before symptom onset (Tofler et al., 1990; Willich et al., 1991; Tofler et al., 2017) with, for instance, outbursts of anger quadrupling the risk (Mostofsky et al., 2014). With the undeniable role of thrombosis in ACS (Abbate et al., 2012), the literature provides good evidence that stress-indu ced coagulation activation is a crucial process in emotionally-triggered ACS (Thrall et al., 2007; von Känel, 2015).

Source: Psychoneuroendocrinology - September 14, 2018 Category: Psychiatry Authors: Roland von K änel, Nadja Heimgartner, Monika Stutz, Claudia Zuccarella-Hackl, A. Hänsel, U. Ehlert, P.H. Wirtz Source Type: research