Glucose dependent miR-451a expression contributes to parathyroid hormone mediated osteoblast differentiation

Parathyroid hormone (PTH; amino acid 1 –34, known as teriparatide) has reported promoting differentiation and glucose uptake in osteoblasts. However, how PTH regulates glucose metabolism to facilitate osteoblast differentiation is not understood. Here, we report that PTH promotes glucose dependent miR-451a expression which stimulates o steoblast differentiation. In addition to glucose uptake, PTH suppresses AMPK phosphorylation via PI3K-mTOR-AKT axis thereby preventing phosphorylation and inactivation of octamer-binding transcription factor 1 (OCT-1) which has been reported to act on the promoter region of miR-451a.

Source: Bone - September 13, 2018 Category: Orthopaedics Authors: Anirudha Karvande, Priyanka Kushwaha, Naseer Ahmad, Sulekha Adhikary, Priyanka Kothari, Ashish Kumar Tripathi, Vikram Khedgikar, Ritu Trivedi Tags: Full Length Article Source Type: research