Chondrosarcoma: An Overview of Clinical Behavior, Molecular Mechanisms Mediated Drug Resistance and Potential Therapeutic Targets

Sarcomas are known as a heterogeneous class of cancers arisen in the connective tissues and demonstrated various histological subtypes including both soft tissue and bone origin. Chondrosarcoma is one of the main types of bone sarcoma that shows a considerable deficiency in response to chemotherapy and radiotherapy. While conventional treatment based on surgery, chemo-and radiotherapy are used in this tumor, high rate of death especially among children and adolescents are reported. Due to high resistance to current conventional therapies in chondrosarcoma, there is an urgent requirement to recognize factors causing resistance and discover new strategies for optimal treatment.
Source: Critical Reviews in Oncology Hematology - Category: Cancer & Oncology Authors: Source Type: research