Over 20 years of treatment-free remission after Interferon-alpha monotherapy for Chronic Myeloid Leukemia

Chronic myeloid leukemia (CML) is a clonal malignancy characterized by the acquisition of the chromosomal translocation t(9;22), also termed Philadelphia chromosome [1], resulting in the formation of the BCR-ABL1 fusion protein. Historically, patients treated with chemotherapy such as busulfan or hydroxyurea had a grim prognosis with a median overall survival (OS) of only 4 years [2].
Source: Leukemia Research - Category: Hematology Authors: Tags: Letter to the Editor Source Type: research