Relations of combat stress and posttraumatic stress disorder to 24-hour plasma and cerebrospinal fluid interleukin-6 levels and circadian rhythmicity

Psychoneuroimmunological research offers mounting evidence of a bi-directional communication between the human immune and stress systems both centrally and peripherally, i.e., through the hypothalamic-pituitary-adrenal axis (HPA axis) and the autonomic nervous system (ANS) (Webster Marketon and Glaser, 2008). Acute and chronic stress can lead to a disrupted interplay between these two systems with consequent over-activation and/or dysfunctional regulation of the systemic and local immune response (Dhabhar, 2014; Glaser and Kiecolt-Glaser, 2005; Menard et al., 2017).

Source: Psychoneuroendocrinology - September 10, 2018 Category: Psychiatry Authors: Agorastos Agorastos, Richard L. Hauger, Donald A. Barkauskas, Imanuel R. Lerman, Tobias Moeller-Bertram, Clara Snijders, Uzair Haji, Piyush M. Patel, Thomas D. Geracioti, George P. Chrousos, Dewleen G. Baker Source Type: research