Measurement of plasma HIV-1 RNA below the limit of quantification ( < 20 copies/mL) of commercial assays with the integrase HIV RNA single-copy assay

Plasma HIV-1 RNA or viral load (VL) is frequently measured in both clinical practice and in clinical trials of antiretroviral therapy (ART) using FDA-approved assays such as the Cobas-TaqMan HIV-1 Assay v2.0 (Roche). The Cobas-TaqMan assay provides quantification of viremia ≥20 copies/mL, with lower values reported as:

Source: Journal of Clinical Virology - September 10, 2018 Category: Virology Authors: N. Margot, D. Koontz, S. McCallister, J.W. Mellors, C. Callebaut Tags: Short communication Source Type: research