Apolipoprotein E in Cardiovascular Diseases: Novel Aspects of an Old-fashioned Enigma
The presence of different APOE isoforms represents a well-known risk factor for cardiovascular diseases. Besides the pleiotropic effects of APOE polymorphism on heart and neurological diseases, this review summarizes the less-known functions of APOE and the possible implications for cardiovascular disorders. Beyond the role as lipid transporting protein, its involvement in lipid membrane homeostasis and signaling, as well as its nuclear transcriptional effects suggests a more complex role of APOE, receiving great interest from researchers and physicians from all medical fields.
Source: Archives of Medical Research - Category: Research Authors: Elisa A. Liehn, Victor Ponomariov, Rodica Diaconu, Ioana Streata, Mihai Ioana, Gustavo E. Crespo-Avilan, Sauri Hern ández-Reséndiz, Hector A. Cabrera-Fuentes Tags: Review Article Source Type: research