Protective effect of the riboflavin-overproducing strain Lactobacillus plantarum CRL2130 on intestinal mucositis in mice

Mucositis refers to mucosal inflammation and frequently occurs as a side effect of cancer treatments such as chemotherapy and radiation therapy. Fluorouracil (5-FU) is one of the most prescribed chemotherapeutic agents because of its ability to interrupt DNA synthesis and stimulate cell apoptosis [1]. However, one important limitation of 5-FU use is that this drug is not cell-specific because of cytotoxic exertion on both cancerous and other fast-reproducing cells [2]. In this sense, the intestinal epithelium is one of the tissues most sensitive to 5-FU because it is one of the most rapidly renewing tissues in adult mammals.
Source: Nutrition - Category: Nutrition Authors: Tags: Basic nutritional investigation Source Type: research