Simvastatin therapy in adolescent mice attenuates HFD-induced depression-like behavior by reducing hippocampal neuroinflammation

Worldwide, obesity is one of the major public health problems and the number of cases were doubled over the last three decades. Including children and adolescents, overconsumption of energy-dense food is the major cause of becoming overweight or obese (Ervin  and Ogden, 2013). Along with co-morbidities such as cardiovascular diseases, metabolic disorders and some cancers, obesity was found to cause hyperlipidemic disorders, cognitive deficits and mood disorders in humans (Francis and Stevenson, 2013).
Source: Journal of Affective Disorders - Category: Neurology Authors: Source Type: research