Current Concepts in Acne Pathogenesis: Pathways to Inflammation.

Current Concepts in Acne Pathogenesis: Pathways to Inflammation.
Semin Cutan Med Surg. 2018 Jun;37(3S):S60-S62
Authors: Tan JKL, Stein Gold LF, Alexis AF, Harper JC
Abstract
Acne is a disease of pilosebaceous inflammation. Pivotal in pathogenesis are the roles of hormones (insulin, insulin-like growth factor-1, androgens), Propionibacterium acnes, lipogenesis, and a proinflammatory lipid profile. Innate immune responses are induced through interaction with toll-like receptors and inflammasome activation initially and subsequently through adaptive immune activation. These insights into pathogenic inflammatory pathways can translate into novel therapeutic approaches for acne. Semin Cutan Med Surg 37(supp3):S60-S62 ©2018 published by Frontline Medical Communication.
PMID: 30192343 [PubMed - in process]

Source: Seminars in Cutaneous Medicine and Surgery - September 9, 2018 Category: Dermatology Tags: Semin Cutan Med Surg Source Type: research