Metabolic-inflammatory status as predictor of clinical outcome at 1-year follow-up in patients with first episode psychosis

Metabolic abnormalities and peripheral inflammation have been increasingly reported in patients with psychosis, often already at illness onset (Hepgul et al., 2012; Pillinger et al., 2017b; Russell et al., 2015). The combination of overweight, dyslipidaemia, hyperglycaemia and peripheral immune activation can lead to severe cardiovascular diseases, like metabolic syndrome, and to increased mortality in patients with psychosis (Leonard et al., 2012; Ringen et al., 2014). However, the consequences of this abnormal metabolic-inflammatory state for the psychiatric/mental health clinical outcome in patients at the onset of psychosis remain undetermined.

Source: Psychoneuroendocrinology - September 8, 2018 Category: Psychiatry Authors: Maria Antonietta Nettis, Giulio Pergola, Anna Kolliakou, Jennifer O ’Connor, Stefania Bonaccorso, Anthony David, Fiona Gaughran, Marta Di Forti, Robin M. Murray, Tiago Reis Marques, Giuseppe Blasi, Alessandro Bertolino, Carmine M. Pariante, Paola Dazzan Source Type: research