Genetic diversity of Hepatitis C Virus in Pakistan using Next Generation Sequencing

Nearly 3% of the World ’s population is infected with Hepatitis C Virus (HCV) that is a leading cause of liver disease [1]. HCV belongs to family Flaviviridae and classified into seven major genotypes and many subtypes based on sequence variability [2,3]. The most significant feature of HCV is that it becomes chronic in nearly 50-80% of individuals. [4]. There is no vaccine against HCV. The current standard of care is the use of direct acting antiviral agents (DAAs) and has shown high SVR (Sustained Virological Response) rate [5].

Source: Journal of Clinical Virology - September 8, 2018 Category: Virology Authors: Sana Saleem, Amjad Ali, Bushra Khubaib, Madiha Akram, Zareen Fatima, Muhammad Idrees Source Type: research