Chemical classes targeting energy supplying GyrB domain of Mycobacterium tuberculosis

Tuberculosis (TB) is contagious in nature and immunocompromised patients have a higher probability of developing TB. The occurrence of drug resistance, has led to serious health concerns in the management of TB. In order to combat resistant tuberculosis there is an urgent need of identifying new drug targets and new drug combinations for the effective management and reduction in the duration of TB treatment. Targeting DNA gyrase that is involved in bacterial replication cycle, provides one rationale approach.
Source: Tuberculosis - Category: Respiratory Medicine Authors: Tags: Review Source Type: research