GWAS and Systems Biology Analysis of Depressive Symptoms among Smokers from the COPDGene Cohort

Major depressive disorder (MDD) is the most common psychiatric disorder in the United States, with an estimated prevalence of 17% (Kessler  et al., 2005). Depression is likely a heterogenous disorder with multiple synergetic effects from many genetic variants; however, a single genetic susceptibility factor with a large effect size has not been found. Though twin studies such as the one led by Kendler et al. (2006) support a genet ic predisposition influencing depression, until recently, depression genome-wide association studies (GWAS) have not shown genome-wide significance in almost all studies reported (Flint and Kendler, 2014).

Source: Journal of Affective Disorders - September 7, 2018 Category: Neurology Authors: Jonathan T. Heinzman, Karin F. Hoth, Michael H. Cho, Phuwanat Sakornsakolpat, Elizabeth A. Regan, Barry J. Make, Gregory L. Kinney, Frederick S. Wamboldt, Kristen E. Holm, Nicholas Bormann, Julian Robles, Victor Kim, Anand S. Iyer, Edwin K. Silverman, Jam Tags: Research paper Source Type: research