Estimation of dermal absorption parameters of cleaning chemical ingredients

Publication date: Available online 7 September 2018Source: Journal of Chemical Health and SafetyAuthor(s): Nishith Ghosh, Pallavee V.K., J.D. Sharma, A.S. VajarekarCleaning workers experience occupational hazards, such as skin diseases and respiratory illness, due to their exposure to the ingredients of cleaning chemicals. To control chemical exposure through inhalation route, airborne concentration of the chemicals is maintained within its occupational exposure limits (OELs). However, universally accepted OELs for dermal exposure are lacking. Unavailability of experimentally determined values of dermal absorption parameters is one of the reasons behind it. Herein, we estimated the dermal absorption parameters (e.g., octanol–water partition coefficient, skin permeability coefficient and maximum flux of chemical across the skin) of a number of cleaning chemical ingredients. Atom/Fragment Contribution (AFC) method was used to estimate octanol–water partition coefficients. The skin permeability coefficients were estimated using the Potts and Guy correlation equation. The estimated skin permeability coefficients were used to estimate maximum flux of the chemicals across the skin. Estimated values of these parameters were compared to that of the chemicals for which ACGIH assigned a “skin” notation. The skin permeability coefficients of the cleaning chemical ingredients were found as similar to that of the chemicals having ACGIH “skin” notation. However, the maximum flu...
Source: Journal of Chemical Health and Safety - Category: Chemistry Source Type: research