Low serum concentration of free triiodothyronine (FT3) is associated with increased risk of Alzheimer ’s disease

Thyroid hormone (TH) receptors are widely expressed in the brain (Wallis et al., 2010). THs are essential for the development of the central nervous system (CNS) during perinatal growth, and also influence the adult CNS by promoting neurogenesis, myelination and cellular repair (Lin et al., 2011; Remaud et al., 2014). Late in life, serum levels of thyroid-stimulating hormone (TSH) and unbound levels of the bioactive triiodothyronine (T3) decline, while free levels of thyroxine (T4), often viewed as a prohormone to T3, are maintained (Boelaert, 2013).
Source: Psychoneuroendocrinology - Category: Psychiatry Authors: Source Type: research