Advances in Detection Methods of β-Amyloid Protein

Publication date: September 2018Source: Chinese Journal of Analytical Chemistry, Volume 46, Issue 9Author(s): Meng JIANG, Xiao-Ying WANG, Xiao-Bing WANGAbstractAlzheimer's disease (AD) is a neurodegenerative disease with unknown etiology. β-amyloid protein (Aβ) is one of the specific biomarkers of AD, and many clinical studies suggest that abnormal levels of Aβ in blood, cerebrospinal fluid and brain tissue are closely related to the progression of AD. The analysis and evaluation of Aβ are important for early detection, tracking, prevention, and treatment of AD. In this paper, the present situations of the commonly used detection methods of Aβ at home and abroad were summarized and compared. Specifically, the latest application of new electrochemical biosensor in Aβ detection was mainly described, and the summary of its future directions and the potential applications was given.Graphical abstractThe present situation of the commonly used Aβ detection methods including neuroimaging, optics and immunoassay was summarized and compared in this paper. Specifically, the application of new electrochemical biosensor in Aβ detection was described. They were divided into six categories based on the different recognization elements. Their respective principles, characteristics and the latest research progress were discussed in detail. Furthermore, the summary of the future directions and the potential applications was given.
Source: Chinese Journal of Analytical Chemistry - Category: Chemistry Source Type: research