Research Advances in Ion Channel-based Electrochemical Sensing Techniques

Publication date: September 2018Source: Chinese Journal of Analytical Chemistry, Volume 46, Issue 9Author(s): Xiao-Jing JIANG, Rong-Ning LIANG, Wei QINAbstractDuring the past few years, the electrochemical sensing techniques based on ion channels have attracted considerable attention. Nowadays, these techniques have been widely used in DNA sequencing, measurement of molecular interactions, and detection of inorganic ions and biological species. Hence, in this review, the research progresses of the ion channel-based electrochemical techniques including amperometry, conductometry and potentiometry in chemical and biological sensing are addressed from the perspective of different electrochemical methods. The sensing mechanism and fabrication process of these sensing methods are mainly introduced. In addition, the further research orientations of the electrochemical sensing based on ion channels are prospected.Graphical abstractThe mechanism of ion-channel electrochemical sensing techniques is as follows: Ion channel is used as the recognition element for the analyte. When the channel is in contact with the sample, it will selectively interact with the analyte. Such interaction will block the indicator transfer across the channel, thus resulting in electrochemical signals. In this review, the research progresses of these techniques including amperometry, conductometry and potentiometry in chemical and biological sensing are addressed from the perspective of different electrochemi...
Source: Chinese Journal of Analytical Chemistry - Category: Chemistry Source Type: research