A randomized trial of transdermal and oral estrogen therapy in adolescent girls with hypogonadism

Conclusions: Treatment with transdermal 17β estradiol resulted in higher estradiol levels and more effective feminization compared to oral conjugated equine estrogen but did not result in an otherwise different biochemical profile in this limited number of heterogeneous patients. OBE and TBE provide safe and effective alternatives to OCEE to induce puberty in girls, but larger prospective randomized trials are required.Trial registrationClinical Trials Identifier: NCT01023178.
Source: International Journal of Pediatric Endocrinology - Category: Endocrinology Authors: Source Type: research