Issues in preclinical radiopharmaceutical research: Significance, relevance and reproducibility

The use of radiolabeled compounds for in vivo preclinical animal studies – broadly considered here as the quantification of the distribution of radioactivity after administration of a radiolabeled chemical to a living animal such as a rodent or nonhuman primate – has steadily increased in recent years, becoming a much more widely used method for studying biochemistry , physiology and pharmacology. Although once a narrow field with results published in a handful of specialty journals in radiology and nuclear medicine, the methods utilized for preclinical in vivo radiotracer studies have now become more accepted and papers using such appear regularly in leading jo urnals in the fields of medicinal chemistry, neurology, cardiology and oncology.
Source: Nuclear Medicine and Biology - Category: Nuclear Medicine Authors: Source Type: research