Granular B-Acute Lymphoblastic Leukemia: Ultrastructural Characterization of Cytoplasmic Granules

The presence of cytoplasmic granules in the blasts is a well-known feature of acute leukemia with myeloid differentiation, whereas cases of B-acute lymphoblastic leukemia (B-ALL) with cytoplasmic granules in blasts are rare and potentially may be misdiagnosed as acute myeloid leukemia. Cases of B-ALL with cytoplasmic granules have been described most often in pediatric patients and others have proposed a criterion for granular ALL being more than 5% of lymphoblasts having three or more clearly defined azurophilic granules [1].
Source: Leukemia Research - Category: Hematology Authors: Tags: Letter to the Editor Source Type: research