Retrospective analysis of 36 fusion genes in 2479 Chinese patients of de novo acute lymphoblastic leukemia

Fusion genes are the main molecular biological abnormalities of hematological malignancies. They exist stably with tumor cells and are well established as diagnostic and prognostic markers for leukemia. They can also be used as molecular markers for monitoring minimal residual disease (MRD) with high sensitivity [1 –4]. Based on their essential role in the mechanisms of tumorigenesis, the WHO classification of neoplastic diseases of the hematopoietic and lymphoid tissues has incorporated some fusion genes into the diagnostic criteria for leukemia since 2000 [5].
Source: Leukemia Research - Category: Hematology Authors: Tags: Research paper Source Type: research