Widespread white-matter microstructure integrity reduction in first-episode schizophrenia patients after acute antipsychotic treatment

Potential effects of initiating acute antipsychotic treatment on white matter (WM) microstructure in schizophrenia patients remain poorly characterized. Thirty-five drug-na ïve first-episode schizophrenia patients were scanned before and after six weeks of treatment with second-generation antipsychotic medications. Nineteen demographically matched healthy subjects were scanned twice over the same time interval. Tract-based spatial statistics was used to test for chang es in WM microstructural integrity after treatment.
Source: Schizophrenia Research - Category: Psychiatry Authors: Source Type: research