Risk stratification of cervical disease using detection of human papillomavirus (HPV) E4 protein and cellular MCM protein in clinical liquid based cytology samples

Clinically insignificant cervical disease represents transient, asymptomatic HPV infections that are cleared by the immune system [1]. Clinically significant infections are not cleared/not detected by the immune system leading to persistent infections that can progress to cancer [2,3]. The high prevalence of clinically insignificant HPV infections, particularly in young women, means the HPV DNA tests in clinical use can lack specificity because they detect presence or absence of viral nucleic acid but cannot measure virus activity.

Source: Journal of Clinical Virology - August 31, 2018 Category: Virology Authors: Andrew Stevenson, Kim Kavanagh, Jiafeng Pan, Lynne Stevenson, Heather Griffin, John Doorbar, Evelyn Scott, Miriam Deeny, Kate Cuschieri, Sheila V. Graham Source Type: research