A mathematical model of dysfunction of the thalamo-cortical loop in schizophrenia

Conclusion: Our model can explain functional differences seen between EEG records of healthy subjects and schizophrenia patients on a system theoretic basis. Because of this and its predictive character, the model may be considered to pave the way towards an early and reliable clinical detection of schizophrenia that is dependent on the interconnections between the thalamic and cortical regions. In particular, the model parameter that describes the strength of this connection can be used for a diagnostic classification of schizophrenia patients.
Source: Theoretical Biology and Medical Modelling - Category: Biomedical Science Authors: Source Type: research