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Patients in the study group had biopsy proved, high grade UTUC as well as a visible lesion on axial imaging and underwent neoadjuvant chemotherapy followed by RNU. By comparison, patients who had biopsy proved, high grade UTUC but no visible lesion on axial imaging underwent RNU alone. Neoadjuvant chemotherapy was not offered to patients with CIS on ureteroscopic biopsy only. Patients in our study group likely had increased rates of CIS on final surgical pathology because CIS is conventionally unresponsive to chemotherapy, and as a result CIS was the only residual disease in patients who responded effectively to neoadjuvant chemotherapy.
Source: The Journal of Urology - Category: Urology & Nephrology Tags: Letter to the Editor/Errata Source Type: research