Vhl deficiency in osteocytes produces high bone mass and hematopoietic defects

Tissue oxygen (O2) levels vary during development and disease; adaptations to decreased O2 (hypoxia) are mediated by hypoxia-inducible factor (HIF) transcription factors. HIFs are active in the skeleton, and stabilizing HIF- α isoforms cause high bone mass (HBM) phenotypes. A fundamental limitation of previous studies examining the obligate role for HIF-α isoforms in the skeleton involves the persistence of gene deletion as osteolineage cells differentiate into osteocytes. Because osteocytes orchestrate skeletal devel opment and homeostasis, we evaluated the influence of Vhl or Hif1a disruption in osteocytes.

Source: Bone - August 30, 2018 Category: Orthopaedics Authors: Gabriela G. Loots, Alexander G. Robling, Jiun C. Chang, Deepa K. Murugesh, Jamila Bajwa, Cameron Carlisle, Jennifer O. Manilay, Alice Wong, Clare E. Yellowley, Damian C. Genetos Tags: Full Length Article Source Type: research